INFLUENCE OF RESERPINE ON CORTISOL PRODUCTION IN THE DOG

Publisher Website
Google Scholar
Abstract
Reserpine is generally agreed to exert its primary action on the central nervous system. However, its influences upon endocrine function are still imperfectly understood (Gaunt, Chart & Renzi, 1963). Regarding the effects of reserpine on the hypothalamo-pituitary-adrenal system, interest has centred upon the possibility that it influences the neurohumoral control of adrenocorticotrophic hormone (ACTH) release (Gaunt et al. 1963; Moses, 1964). The possibility of a direct adrenal corticotrophin-like action of reserpine has also been suggested (Moses, 1964). In order to test the latter hypothesis, the following experiments were performed. Under pentobarbital anaesthesia, two mongrel dogs in each experiment were hypophysectomized by a transpalatal approach. One dog served solely as a donor of arterial blood. In the second dog, the isolated adrenal pouch preparation in situ of Hilton, Weaver, Muelheims, Glaviano & Wégria (1958) was used. The isolated adrenals were entirely perfused by the donor's arterial blood. Thus, influences of the

This publication has 0 references indexed in Scilit: