Indolyl-3-acryloyl-glycine and the ‘Light Baud’ in Chronic Polymorphous Light Dermatosis

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Abstract
Mixtures of substances absorbing at about 494 m[mu] and at 510 ran produce broad, dome-shaped extinction bands resembling the natural "lieht band". The exact position of the maximum depends on the quantitative proportions between these substances. With artificial mixtures of indolyl-3-acryloly-glyclne [(IAcrGly) 510 m[mu]] and tndole-3-acrylic- acid (494 m[mu]) many intermediate maxima are obtained. The same effect is found by administering indole-3-proprionic actd to a patient with liver disease who excretes large quantities of uro-bilin and IAcrGly. These compounds axe demonstrated by determination of urobilinogen and chromatography of indoles. The light band probably is tie result of urobilin and IAcrGly, but other urine components such as chlororubine, uroerythrine are also found in the band. Since IAcrGly disappears completely from the urine after sterilization of the intestines, it is assumed that the band is caused by 2 products of intestinal flora, urobilinogen and IAcrGly, which are both converted to red substances in the concentrated acid "light band" extract. It is suggested that there is a connection between sensitivity to sunlight and liver or intestinal function.

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