Digoxin-rifampin interaction
- 1 June 1984
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 35 (6) , 750-754
- https://doi.org/10.1038/clpt.1984.106
Abstract
Digoxin [used to treat hypertensive ischemic heart disease] doses required to maintain therapeutic serum concentrations rose substantially in 2 patients dependent on dialysis with the commencement of rifampin therapy [for an intractable infection of a polytetrafluorethylene graft by Staphylococcus aureus]. When rifampin was discontinued, doses fell to requirements before rifampin. Serum digoxin concentration may fall to ineffective levels with rifampin therapy and rise to potentially toxic levels when rifampin is discontinued.This publication has 5 references indexed in Scilit:
- Digoxin biotransformationClinical Pharmacology & Therapeutics, 1984
- Biotransformation and elimination of digoxin with normal and minimal renal functionClinical Pharmacology & Therapeutics, 1979
- Inhibition of Digoxin Absorption by NeomycinGastroenterology, 1976
- Rifampin-Induced Methadone WithdrawalNew England Journal of Medicine, 1976
- Biliary excretion of digoxin in manClinical Pharmacology & Therapeutics, 1976