Protein Binding and Vascular Activity of Diazoxide
- 20 November 1969
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 281 (21) , 1141-1145
- https://doi.org/10.1056/nejm196911202812102
Abstract
Diazoxide is a potent arteriolar dilator effective in severe hypertension. Its pharmacokinetics show three unusual features. To achieve maximal hypotensive action the drug must be injected rapidly intravenously. The plasma half-life (26 hours) greatly exceeds the duration of its vascular activity (four to eight hours). Plasma levels of diazoxide do not correlate with the intensity of its hypotensive action.Keywords
This publication has 9 references indexed in Scilit:
- The Binding of Drugs by Plasma ProteinsJournal of Pharmaceutical Sciences, 1968
- Intravenous Use of Diazoxide in the Treatment of Severe HypertensionCirculation, 1968
- Diazoxide blood levels in manJournal of Pharmaceutical Sciences, 1967
- Studies on the Coumarin Anticoagulant Drugs: Interaction of Human Plasma Albumin and Warfarin Sodium*Journal of Clinical Investigation, 1967
- Clinical Evaluation of DiazoxideCirculation, 1963
- The Acute Hemodynamic Effects of Diazoxide in ManCirculation, 1963
- A theory of drug action based on the rate of drug-receptor combinationProceedings of the Royal Society of London. B. Biological Sciences, 1961
- SOME QUANTITATIVE ASPECTS OF THE BINDING OF QUINIDINE AND RELATED QUINOLINE COMPOUNDS BY HUMAN SERUM ALBUMIN*Journal of Clinical Investigation, 1961
- Some General Aspects of Molecular InteractionsPublished by Elsevier ,1958