Cell‐mediated immune reactions in asthma

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Abstract
Abnormally high levels of Ig[immunoglobulin]E are produced in various diseases, including atopic eczema, and a functional decrease in the T[thymus derived]-lymphocyte population occurs at the same time. T-cell function was studied in a group of asthma patients with high, normal and low IgE levels and in a control group. T-cell function appeared to be reduced in asthmatic patients with high concentrations of IgE when skin tests were performed with Candida antigen (P < 0.05). There was also a decline in the lymphocyte transformation tests with Candida antigen in autologous serum (P < 0.05), although not in fetal celf serum. The responses to in vivo tests with streptokinase-streptodornase were normal, as was the response of the lymphocytes to PHA [phytohemagglutinin].

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