Antigen Recognition by Human γδ T Lymphocytes

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Abstract
Mature T lymphocytes carrying the conventional αβ T cell receptor (TCR) recognize peptide antigens in the context of MHC class I (CD8+) and MHC class II (CD4+) antigens, respectively. In striking contrast, human γδ T lymphocytes recognize unconventional antigens via their heterodimeric TCR in a non-MHC-restricted fashion. In this brief review, we discuss recent progress in the identification of ligands that are specifically recognized by human γδ T cells. It appears that γδ T cells have evolved to supplement the cellular immune response towards antigens that are not seen by αβ T lymphocytes.