Lymphopenia and lymphocyte transformation in alcoholics
- 1 February 1979
- journal article
- specialia
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 35 (2) , 268-269
- https://doi.org/10.1007/bf01920656
Abstract
Summary The basis of peripheral blood lymphopenia observed in patients with chronic alcoholism and liver disease was investigated by examining the effect of sera of these patients on in vitro transformation of normal human peripheral blood lymphocytes. A positive correlation was demonstrated between the serum inhibition of phytohaemagglutinin- and pokeweed mitogen-induced transformation and the degree of lymphopenia. Thus serum factors may contribute to the observed lymphopenia by inhibiting lymphocyte production in vivo.Keywords
This publication has 3 references indexed in Scilit:
- REDUCTION IN CIRCULATING T LYMPHOCYTES IN ALCOHOLIC LIVER DISEASEThe Lancet, 1974
- Depression of lymphocyte reactivity to phytohemagglutinin by serum from patients with liver diseaseCellular Immunology, 1973
- Inhibition of PHA-stimulated lymphocyte transformation by plasma from patients with advanced alcoholic cirrhosis.1971