Cyclonucleosides Related to Adenosine and Tubercidin
Open Access
- 1 January 1973
- journal article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 37 (2) , 301-305
- https://doi.org/10.1271/bbb1961.37.301
Abstract
Treatment of N6, N6-dibenzoyl-2', 3'-O-isopropylidene-5'-O-mesyladenosine (IV) with an equimolar amount of sodium hydroxide afforded a cyclonucleoside, IX, which was furthur converted to an imidazole cyclonucleoside, VI, with excess sodium hydroxide. In aqueous acetic acid VI was converted to a cyclonucleoside, XIII, which suffered from furthur degradation on mild alkaline hydrolysis giving a cyclonucleoside, XIV. In the tubercidin (7-deaza-adenosine) series the reaction proceeded analogously.Keywords
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