Hemolytic Effect of Sulfonamides in Patients with Erythrocytes Deficient in Glucose-6-Phosphate Dehydrogenase

Publisher Website
Google Scholar
Abstract
TREATMENT of infection often necessitates the use of drugs that can cause hemolytic reactions in patients with erythrocytes deficient in glucose-6-phosphate dehydrogenase (G-6-PD). Nitrofurantoin and sulfonamides, among others, may cause hemolysis in susceptible patients.1 , 2 Because sulfonamides are among the agents most frequently chosen for treatment of infections of the urinary tract,3 it is important to determine if hemolysis is a risk in patients so treated, and if screening for G-6-PD deficiency is of value before therapy is initiated.The prevalence of bacteriuria in clinic populations of pregnant women is 5 to 6 per cent,4 regardless of racial background. One out . . .