Electroanalytical studies of beta-adrenergic blocking agents; N-isopropylethanolamine derivatives; procainamide

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Abstract
The beta-adrenergic blocking agents metoprolol, oxprenolol, pindolol, practolol, propranolol and sotalol, and also the related procainamide, have been examined by anodic rotating disc electrode voltammetry in acidic media and in buffer media over the range of pH from 0 to 11.5. The best medium is 0.1 mol l–1 sulphuric acid, in which most of the compounds show obedience to the Levich relationship at platinum and gold electrodes. Rapid determinations of oxprenolol (up to 5 × 10–3 mol l–1), practolol, propranolol and procainamide give very satisfactory results. Electrode kinetic parameters for mass and charge transfer have been determined for the latter four compounds. Reaction mechanisms have been elucidated and differ for each compound. Cyclic voltammetry has not proved to be particularly informative, and is illustrated for propranolol.

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