Binding protein of somatomedin A in serum from men and rats.

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Abstract
After gel chromatography of human and rat serum at pH 7.4, all endogenous somatomedin A [SMA] was recovered in the high MW range. The largest peak was found in the .gamma.-globin (II) region and the next largest peak found in the albumin region (III). The amounts of SMA in the peak II region increased in serum from acromegalic and decreased in serum from growth hormone deficient patients. Four radioactive peaks were observed after gel chromatography of serum incubated with 125I-SMA. Only the 2 peaks corresponding to peaks II and III out of the 4 peaks were displaced by adding 50 .mu.g of partially purified cold SMA. The radioactivity of peak II decreased in sera from growth hormone deficient patients and increased after growth hormone administration. Growth hormone apparently regulates not only SMA but also its carrier protein.

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