Studies on the Synthesis of Phosphorus Heterocycles I. [1,4,3]Thiazaphosphorino[3,4-b][1,3,2]benzodiazaphosphorine 12-Oxides
- 1 January 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1989 (08) , 618-621
- https://doi.org/10.1055/s-1989-27336
Abstract
N-Substituted isatoic anhydrides 4 react with 2-bromoethylamino hydrobromide in the presence of triethylamine to form oxazolines 6, which are treated with phosphorus trichloride to give a key intermediate 7. Reaction of 7 with phenyl isothiocyanate yields fused phosphorus heterocycles 9. Several methods for preparing compounds 9 and the mechanism of cyclization are discussed.Keywords
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