RENIN AND ALDOSTERONE RESPONSES TO SHORT-TERM NACL OR NAHCO3 LOADING IN MAN

  • 1 January 1982
    • journal article
    • research article
    • Vol. 100  (2) , 261-268
Abstract
The effects of 500 ml of 0.15 M NaCl or 750 ml of 0.15 M NaHCO3 infusions on PRA and PAC [plasma renin activity and plasma aldosterone concentration] were compared in 16 normal NaCl-restricted men. More positive Na balance, greater natriuresis, and lower serum Cl, K, and hydrogen ion concentrations were observed after NaHCO3 infusion. PRA decreased (13.8 .+-. 1.0 ng/ml angiotensin 1/h to 6.6 .+-. 0.70) and PAC did not change (98 .+-. 15 ng/dl to 86 .+-. 15) after NaCl infusion. Conversely, PRA did not change (9.9 .+-. 1.6 to 10.1 .+-. 1.6) and PAC decreased (85 .+-. 9 to 44 .+-. 5) after NaHCO3 infusion. Plasma cortisol declined in both groups. In Na-restricted man Cl is more important that Na for the suppression of PRA by NaCl loading and K or hydrogen ion is a more sensitive modulator of aldosterone secretion than is renin.

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