Gc Serum groups and schizophrenia

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Abstract
In an epidemiological study of schizophrenia in a North Swedish isolate, Book et al. (1978) reported an association between schizophrenia and the genetic marker Gc2 (group specific component-2). To confirm this observation, a series of schizophrenic patients from Vasterbotton County in Northern Sweden were examined. There was no difference between schizophrenic patients and controls with respect to the frequencies of Gc groups of genes. A reanalysis of the material by Book et al. (1978) showed that schizophrenics compared to controls had a significant increase in the frequency of the Gc 2-1 group, but not of the Gc2 gene. The Gc distribution in the material by Book et al. (1978) was similar to that previously reported in a series of patients with cycloid psychosis.