Involvement of the intestinal microflora in the formation of sulphur-containing metabolites of caffeine
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 11 (11) , 771-778
- https://doi.org/10.3109/00498258109045881
Abstract
1. The urine of conventional and germ-free rats was examined, after an oral dose of caffeine, with regard to the presence of sulphur-containing conjugates of this compound. 2. Only the methyl sulphoxide analogue was detected. 3. The ratio of the quantities of this metabolite in conventional and germ-free rat urine was 42:1. 4. The proposed mechanism for the formation of the methyl sulphoxide analogue of caffeine involves the biliary excretion of a mercapturic acid pathway metabolite of caffeine with subsequent metabolism by the intestinal microflora.This publication has 18 references indexed in Scilit:
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