Genotypic variation of HIV-1 reverse transcriptase and protease: comparative analysis of clade C and clade B

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Abstract
To compare drug-resistant variants from untreated (naive) and treated patients infected with clade B or C virus. Consecutive samples (165) from patients throughout Israel were analyzed. All those in the treated group were failing highly active antiretroviral therapy. There were 78 clade C (20 naive) and 87 clade B (14 naive) with significant differences in the prevalence of known drug-resistance mutations between the clades: in naive patients in the protease region M36I 7% and 95% (P P Significantly differences between clade B and C viruses may be associated with development of differing resistance patterns during therapy and may affect drug utility in patients infected with clade C.