Toxicity Studies on Nimbidin, a Potential Antiulcer Drug

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Abstract
Nimbidin, a potential antiulcer compound was subjected to detailed toxicity studies in mice, rats and mongrel dogs. In albino rats and mice acute toxicity studies showed no toxicity up to 2000 mg/kg orally and 1000 mg/kg intraperitoneally. LD50 could not be determined since it was difficult to administer the drug in high dose levels, due to its crude insoluble nature. Subacute toxicity studies in albino rats up to 100 mg/kg daily for 6 weeks and 10 and 20 mg/kg orally in dogs for 4 weeks did not evidence any systemic toxicity. Teratogenic studies in rats also did not reveal any toxic manifestations or foetal abnormalities.

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