5-HT1D and 5-HT1E/1F binding sites in depressed suicides: increased 5-HT1D binding in globus pallidus but not cortex
- 1 July 1997
- journal article
- research article
- Published by Springer Nature in Molecular Psychiatry
- Vol. 2 (4) , 314-321
- https://doi.org/10.1038/sj.mp.4000259
Abstract
5-HT1D and 5-HT1E/1F receptor binding sites were measured in brain samples obtained at post-mortem from suicide victims with a firm retrospective diagnosis of depression, and matched controls. In antidepressant-free suicides a significantly higher number of 5-HT1D receptors was found in globus pallidus. This was largely restricted to those suicides who died by violent means. This effect was not observed in antidepressant-treated suicides. No differences or trends in 5-HT1D binding were found in putamen, parietal or frontal cortex, in antidepressant-free or antidepressant-treated suicides. There were no differences in the number of 5-HT1E/1F receptors in any of the regions studied.Keywords
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