In-vitro activity of 21 antimicrobial agents against Neisseria gonorrhoeae in Brussels.

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Abstract
The minimum inhibitory concentrations (MIC) of 21 antimicrobial agents was measured for 80 strains of N. gonorrhoeae isolated in Brussels in 1978. Bimodal distributions were found for penicillin G, ampicillin, amoxycillin, carbenicillin and cephalexin. Of the strains, 17.5% were relatively resistant to penicillin G (MIC > 0.08 .mu.g/ml), 27.5% to ampicillin (MIC > 0.16 .mu.g/ml), 23.8% to amoxycillin and 43.3% to carbenicillin. Cefotaxime was the most active antibiotic, with MIC in the ng range; 3.8% and 5% of the strains were relatively resistant to cephaloridine and cephalexin, respectively, but no strains were resistant to cefazolin, cefuroxime or cefotaxime. Resistance to tetracycline, doxycycline, minocycline, erythromycin and spiramycin (MIC > 1 .mu.g/ml) was found in 6.3%, 2.5%, 2.5%, 5% and 51.3% of the strains, respectively. A very good correlation was present between chloramphenicol and thiamphenicol, with 16.3% and 10% of relatively resistant strains, respectively. Only 2 isolates showed an MIC > 1.25 .mu.g/ml for rifampicin; 10% of the strains needed .gtoreq. 12.mu.g/ml of spectinomycin for complete inhibition of growth. A very high synergy was found for the 20:1 combination of sulfamethoxazole and trimethoprim, with only 1 isolate resistant to this combination. None of the strains tested produced .beta.-lactamase.