THE INFLUENCE OF MECAMYLAMINE ON THE ACTION OF CERTAIN OTHER GANGLIONIC BLOCKING AGENTS * *Work done in Department of Pharmacology, Royal College of Surgeons of England, London.

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Abstract
Hexamethonium is shown to produce neuromuscular block in cats previously given mecamylamine. Trimetaphan camphorsulphonate is shown to have a similar but less marked action at the motor endplate under the same conditions. The mechanism by which mecamylamine modifies the action of these ganglion blocking agents is discussed. Attention is drawn to the potential risk if similar influences prevail in man.

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