COMPARATIVE-STUDY INVITRO BETWEEN RABIES AND RABIES RELATED VIRUSES BY SENSITIZED LYMPHOCYTES TECHNIQUE

  • 1 January 1976
    • journal article
    • research article
    • Vol. A127  (3) , 429-438
Abstract
Rabbit lymphocytes obtained from animals previously exposed to rabies virus undergo a specific lymphoblastic transformation when incubated in vitro in the presence of either the complete virus or a nucleocapsid fraction. This type of in vitro transformation was observed by the Pasteur, Lagos, Mokola, Obodhiang viruses and the virus [strain] HBP in cells originally exposed only to the virus HEP. In addition to the morphological changes of lymphoblastic transformation, 3H-thymidine incorporation was stimulated about 21-67 fold in homologous system and about 6-39 in heterologous systems and unrelated with other virus system like influenza. An immunological relationship between the classic rabies strains (HEP, Pasteur) and subgroup rhabdovirus (Lagos, Mokola, Obodhiang) is suggested.

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