NEOPLASTIC EFFECTS OF ORAL-ADMINISTRATION OF (+/-)-TRANS-7,8-DIHYDROXY-7,8-DIHYDROBENZO[A]PYRENE AND THEIR INHIBITION BY BUTYLATED HYDROXYANISOLE
- 1 January 1979
- journal article
- research article
- Vol. 62 (4) , 1103-1106
Abstract
The neoplastic effects of administration of benzo[a]pyrene (BP) and (.+-.)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP 7,8-dihydrodiol) by oral intubation to noninbred female Ha:ICR mice were determined. Under the experimental conditions, BP induced papillomas of the forestomach. BP 7,8-dihydrodiol also induced papillomas of the forestomach and was more potent than BP. Administration of BP 7,8-dihydrodiol caused a large number of pulmonary adenomas and lymphomas. Butylated hydroxyanisole (BHA) added to the diet at a concentration of 5 mg/g inhibited BP-induced neoplasia of the forestomach. BHA also inhibited neoplasia of the forestomach, lungs, and lymphoid tissue that was caused by administration of BP 7,8-dihydrodiol. The inhibitory effect of BHA on BP carcinogenesis may entall events that occur subsequent to the formation of BP 7,8-dihydrodiol.This publication has 16 references indexed in Scilit:
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