HORMONAL EFFECTS ON THE NUCLEIC ACID AND PHOSPHOLIPID TURNOVER OF RAT LIVER AND THYMUS1

Publisher Website
Google Scholar
Abstract
Within the last decade pioneer work by Scandinavian investigators (Caspersson, 1940; Caspersson and Schultz, 1940; Euler and Hevesy, 1942; 1944; Andreasen and Ottensen, 1944; 1945; and Hevesy, 1946) has correlated the turnover of nucleic acids with the rate of growth of certain tissues. Similar findings have also been reported by Brues and his coworkers (1942; 1944), and by Marshak et al. (1941; 1945), working with isolated nuclei. The work of Claude (1943; 1944) has also shown the close connection with growth ofnucleic acids and phospholipids in several relatively separate components of cytoplasm. It is well known that hyperthyroid animals possess significantly heavier livers than do normal ones, that the administration of adrenal steroids and of pituitary adrenocorticotropic hormone causes a marked decrease in thymus weight, and that hypophysectomized animals do not gain weight whereas the same animals gain more than normal growing animals if treated with growth hormone.