Interactions of Phencyclidine Receptor Agonist MK‐801 with Dopaminergic System: Regional Studies in the Rat
- 1 April 1990
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 54 (4) , 1157-1162
- https://doi.org/10.1111/j.1471-4159.1990.tb01943.x
Abstract
Interactions of the potent phencyclidine receptor agonist MK-801 with the dopaminergic system were examined in various brain regions in the rat. MK-801 increased dopamine (DA) metabolism in the pyriform cortex, entorhinal cortex, prefrontal cortex, striatum, olfactory tubercle, amygdala, and septum without affecting DA metabolism in the cingulate cortex and nucleus accumbens. In pyriform cortex and amygdala, MK-801 was more potent than phencyclidine at increasing DA metabolism. Local injections of MK-801 into ventral tegmental area and into the amygdala/pyriform cortex interface indicated that MK-801 may act at the cell body as well as the nerve terminal level to increase DA metabolism and that ongoing dopaminergic neuronal activity is a prerequisite for full drug action.Keywords
This publication has 27 references indexed in Scilit:
- Differential effects of phencyclidine (PCP) and ketamine on mesocortical and mesostriatal dopamine releaseLife Sciences, 1989
- Differential Control by N‐Methyl‐D‐Aspartate and Kainate of Striatal Dopamine Release In Vivo: A Trans‐Striatal Dialysis StudyJournal of Neurochemistry, 1988
- Classification and nomenclature of phencyclidine and sigma receptor sitesTrends in Neurosciences, 1987
- Effects of phencyclidine on the release and synthesis of newly formed dopamineNeuropharmacology, 1983
- Selective effects of buspirone and molindone on dopamine metabolism and function in the striatum and frontal cortex of the ratNeuropharmacology, 1983
- A selected ion monitoring assay for dopamine and its metabolites using negative chemical ionizationJournal of Mass Spectrometry, 1982
- Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic propertiesDrug Development Research, 1982
- Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic propertiesDrug Development Research, 1982
- Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic propertiesDrug Development Research, 1982
- Differential effect of acute and chronic ethanol on dopamine metabolism in frontal cortex, caudate nucleus and substantia nigraLife Sciences, 1980