TOTAL-BODY SCINTIGRAPHY WITH I-131-META-IODOBENZYLGUANIDINE FOR DETECTION OF NEURO-BLASTOMA
- 1 January 1985
- journal article
- research article
- Vol. 54 (1) , 21-27
Abstract
Total-body scintigraphy with 131I-m-iodobenzylguanidine (131I-MIBG) was performed in 20 patients with neuroblastoma. In patients who were in complete remission no pathological concentration of 131I-MIBG was found. In 16 patients with residual, recurrent or metastatic neuroblastoma the tumor localizations were correctly identified by 131I-MIGB-stinctigraphy. In 5 patients additional tumor sites were found. In most patients an inverse relationship between myocardial and tumoral concentration of 131I-MIBG was noted. Dosimetric assessment of 131I-MIBG uptake in patients with metastatic disease revealed cases with considerable tracer concentration and long effective half lives in tumor localizations. 131I-MIBG total-body scintigraphy is useful in the diagnosis and follow-up of neuroblastoma, and therapeutic use of this agent is feasible, if patients are selected upon the merits of dosimetry.This publication has 7 references indexed in Scilit:
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