Thrombosis in coronary heart disease.

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Abstract
Thrombosis seems to be the final common path of a number of different etiological factors, in the majority of patients with coronary heart disease. The tendency to intravascular thrombosis, or its presence, is reflected by abnormal platelet behavior, which seems likely to be an indicator of other abnormalities in the blood. In this, evidence is mounting that the role, particularly of the catecholamines, free fatty acids, and the red blood cells may be of considerable importance. Studies support, but do not yet completely prove that disease of the arterial walls is associated with platelet changes and thrombus formation. The predictive value of platelet changes in the development of ischemic heart disease merits further study. The correction of platelet abnormalities in ischemic heart disease, by diet or drugs, opens up new possibilities for antithrombotic as opposed to anticoagulant measures, in prophylaxis and management of the disease.