Carbamazepine versus Diphenylhydantoin in the Treatment of Myotonia
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in European Neurology
- Vol. 22 (2) , 113-118
- https://doi.org/10.1159/000115546
Abstract
A double-blind controlled trial was performed on 6 patients affected with Steinert’s disease in order to evaluate the efficacy of two different dosages of diphenylhydantoin (PHT, 200 and 300 mg/day) and carbamazepine (CBZ, 600 and 800 mg/day) on the myotonic afterdischarge. Both dosages of PHT and CBZ induced a significant improvement of myotonia. For PHT a trend towards decreased efficacy is pointed out at toxic or at high dosages.Keywords
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