Fragile Xq27 in somatic cells derived from different tissues

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Abstract
Prenatal diagnosis for the Martin‐Bell syndrome resulted in the detection of 4 fragile X‐positive male fetuses and 2 female fetuses. Studies carried out on monolayer cultures derived from various tissues from these show that fra‐Xq27 can be ascertained in cells from testis, lung, kidney, skin, ovary, and muscle. This suggests that the fragility of the X chromosome may be present in all somatic cells. There appears to be no strong correlation between the level of marker detected and the involvement of the tissue from which the cells were derived in the manifestation of the syndrome. The level of fra‐X is dependent rather more on culture conditions than on cell type except for lymphocytes, in which detection is easier.