STUDIES ON MONO-AMINE OXIDASE AND CATECHOL-O-METHYLTRANSFERASE OF RAT CEREBRAL MICROVESSELS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 233  (2) , 227-234
Abstract
The rat cerebral microvessels were isolated and assayed both for monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) activities. Cerebral microvessels and brain filtrate contained both forms (A and B) of MAO. On a per milligram protein basis, the cerebral microvessels contained the greatest activity of MAO and COMT than that of brain filtrate and mesenteric artery. Chemical sympathectomy using 6-hydroxydopamine neither decreased total MAO activity, nor the A form of the enzyme, nor did it have any effect on COMT activity in the brain microvessels. COMT and both forms of MAO in the rat brain microvessels are extraneuronal in origin.

This publication has 3 references indexed in Scilit: