TUBULOINTERSTITIAL NEPHRITIS AND GLOMERULONEPHRITIS IN BROWN-NORWAY RATS IMMUNIZED WITH HETEROLOGOUS GLOMERULAR BASEMENT-MEMBRANE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 88  (1) , 53-68
Abstract
Tubulointerstitial nephritis and glomerulonephritis were produced in Brown-Norway rats (BN) by single immunization with 2 mg of lyophilized bovine glomerular basement membrane. Tubulointerstitial nephritis was evident before glomerulonephritis. Antibody first bound to tubular basement membranes (TBM); then the renal cortex was infiltrated with inflammatory cells. The TBM was split, and many renal tubules, especially proximal, were destroyed. Approximately 14 days after beginning of the tubular phase, antibody apparently was bound to glomerular basement membranes (GBM) linearly. There was epithelial and mesangial cell proliferation, splitting and reduplication of GBM, crescent formation and glomerular scarring and atrophy.