Serum Ceruloplasmin in Liver Cirrhosis

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Abstract
The behavior of serum ceruloplasmin was investigated in liver cirrhosis. Increased levels of Cu protein was found in 21 out of 28 patients with alcoholic cirrhosis and hemo-chromatosis and in all 4 patients with biliary cirrhosis. There was a significant correlation between serum ceruloplasmin and a2-globulin levels. It is suggested that the impairment of biliary excretion and of estrogen metabolism, and the enhancement of [alpha]2-globulin synthesis can account for these findings.