Circadian Component in the Fattening and Reproductive Responses to Prolactin in the Hamster

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Abstract
Prolactin has variable effects on the weights of ovaries and uteri of hamsters depending on the time of day when the injections are made. The photoperiodic entrainment of these daily variations in responses to prolactin is apparently mediated by the adrenal cortex because corticosterone injections can entrain similar response rhythms in hamsters held in continuous light. The estrus cycle appears to be arrested in late diestrus or early proestrus by injections of prolactin at 18 hr after the onset of a 12-hr daily photoperiod or at 12 hr after the injection of corticosterone. The body fat stores are also increased or decreased depending on the temporal pattern of injections of prolactin and corticosterone.

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