Effect of Acetanilide and p-Hydroxyacetanilide on the Carcinogenicity of N-2-Fluorenylacetamide and N-Hydroxy-N-2-fluorenylacetamide in Mice, Hamsters, and Female Rats2
- 1 July 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 51 (1) , 235-240
- https://doi.org/10.1093/jnci/51.1.235
Abstract
Simultaneous dietary administration of acetanilide (AA) or p-hydroxyacetanilide (p-OHAA) with the carcinogen N-2-fluorenylacetamide (FAA) inhibited mammary tumor formation in female Sprague-Dawley-derived rats. p-OHAA had no effect on the mammary tumor incidence from N-hydroxy-2-fluorenylacetamide (N-OHFAA). In male mice on similar regimens, AA was more effective than p-OHAA in reducing the liver cancer incidence from FAA. Neither AA nor p-OHAA altered the yield of bladder tumors induced by FAA in mice. p-OHAA decreased the bladder but not the liver tumor incidence caused by N-OHFAA in male mice. Either AA or p-OHAA reduced the number of liver tumors in female mice fed FAA, and p-OHAA had a similar action with N-OHFAA. Either AA or p-OHAA inhibited liver tumors in male or female hamsters fed FAA, and p-OHAA did likewise with N-OHFAA. The incidence of gastric papillomas and carcinomas From N-OHFAA was not markedly decreased by p-OHAA.Keywords
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