Development of the Ti-Catalyzed Intermolecular Hydroamination of Alkynes
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- 15 July 2004
- journal article
- account
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2004 (10) , 1653-1672
- https://doi.org/10.1055/s-2004-829579
Abstract
This account describes the development of Ti-catalyzed intermolecular hydroamination reactions of alkynes, achieved in the author’s laboratories during the last five years. Starting from initial ideas and early results with Cp2TiMe2 as a catalyst precursor, mechanistic studies and applications of Cp2TiMe2-catalyzed hydroaminations of alkynes for the synthesis of biologically interesting classes of compounds are presented. Particular attention is paid to the identification of improved second generation catalysts such as Cp*2TiMe2 and Ind2TiMe2.Keywords
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