Enzymatic Proteolysis of Rat Sponge Biopsy Collagen Tissue

Abstract
The colla-genolytic effect of certain enzymes upon rat sponge biopsy connective tissue was studied. No difference was noted in the proteolysis of collagen obtained from either sex or from castrate rats. Trypsin, chymotrypsin and papain all have a slight proteolytic activity, while pure elastase and hyaluronidase effect little, if any, liberation of collagen. Impure elastase dissolves 2 to 6 times the amount of collagen digested by the proteolytic enzymes or a combination of pure elastase and trypsin.

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