New cytotoxic principles from Datisca glomerata
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 1333-1347
- https://doi.org/10.1039/p19830001333
Abstract
Datisca glomerata has been systematically fractionated by following cellular toxicity in an effort to identify previously uncharacterized cytotoxic principles. Several new cucurbitacin glycosides, including datiscosides B(8), C(3), D(9), E(4), F(5), G(6), and H(10) and the known compound datiscoside (1), as well as cucurbitacins B(11), D(2), and F(7) have been isolated and characterized. Structures were assigned to the compounds on the basis of their high field 1H n.m.r., 13C n.m.r., high-resolution mass spectra (CI, EI, and FD) and chemical interconversions. The structure of datiscoside C(3) was independently established by single-crystal X-ray analysis at 193 and 293 K.This publication has 5 references indexed in Scilit:
- Steroidal glycosides of Tribulus terrestris LinnJournal of the Chemical Society, Perkin Transactions 1, 1981
- Cucurbitacins as kairomones for diabroticite beetlesProceedings of the National Academy of Sciences, 1980
- Tumor Inhibitors. XXIII.1 The Cytotoxic Principles of Marah oreganus H.2Journal of Medicinal Chemistry, 1967
- Cucurbitacins: Specific Insect Attractants in CucurbitaceaeScience, 1966
- Measurement of Cell Growth in Tissue Culture with a Phenol Reagent (Folin-Ciocalteau)Experimental Biology and Medicine, 1956