Deposition of Tetracyclines in Urinary Calculi
- 21 December 1964
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 190 (12) , 1074-1076
- https://doi.org/10.1001/jama.1964.03070250056021
Abstract
THE DEPOSITION and distribution of tetracyclines in body tissues has been a subject of recent interest. Their deposition in teeth, osseous tissue, and several pathologic lesions has been investigated. Tetracyclines given to patients for infectious disease may be retained as a relatively insoluble complex with calcium in the mineralized tissues. In a manner similar to lead, alizarin, and radioactive isotopes of some elements, tetracyclines are deposited in relatively "hot spots" in the less than 1% of the skeleton which is recognized as exchangeable, reactive, or labile. Urist and Ibsen1 reported that the "oxytetracycline molecule is too large to fit anywhere except on the surface of the apatite crystal and is bound to it." In another report2 they found that organic matrix substances in bone appear to inhibit binding of oxytetracycline. They demonstrated that calcium reacts in a specific stoichiometric proportion to produce a fluorescent complex that appears as brightKeywords
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