RESPIRATORY EFFECTS ON THE FILLING OF THE VENTRICLES DURING A PROLONGED DIASTOLE

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Abstract
Ventricular volume was recorded by means of a cardiometer in the closed chest of anesthetized dogs. The recording system was so arranged that external pressure on the ventricles followed the normal respiratory variations of intrathoracic pressure. Diastole was prolonged by vagal stimulation. Under these conditions, ventricular filling at any stage of diastole is accelerated by inspiration and retarded by expiration. If either inspiration or expiration occurs while filling is in progress, the gradient of the filling curve is altered thereby. Such variations are particularly prominent during the stage of diastasis. The effects described become less conspicuous as the mean level of venous pressure is raised, but are still demonstrable when venous exceeds intrathoracic pressure by 90 mm. of water.

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