Structure/Function Relationships Responsible for the Kinetic Differences between Human Type 1 and Type 2 3β-Hydroxysteroid Dehydrogenase and for the Catalysis of the Type 1 Activity
Open Access
- 1 November 2002
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 277 (45) , 42795-42801
- https://doi.org/10.1074/jbc.m208537200
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- Induction of 3 -Hydroxysteroid Dehydrogenase/ Isomerase Type 1 Expression by Interleukin-4 in Human Normal Prostate Epithelial Cells, Immortalized Keratinocytes, Colon, and Cervix Cancer Cell LinesEndocrinology, 1999
- Site-directed mutagenesis identifies amino acid residues associated with the dehydrogenase and isomerase activities of human type I (placental) 3β-hydroxysteroid dehydrogenase/IsomeraseThe Journal of Steroid Biochemistry and Molecular Biology, 1998
- Mutagenesis of 3α-Hydroxysteroid Dehydrogenase Reveals a “Push−Pull” Mechanism for Proton Transfer in Aldo−Keto ReductasesBiochemistry, 1998
- Functional activity of 3β-hydroxysteroid dehydrogenase/isomeraseEndocrine Research, 1998
- Affinity Radiolabeling Identifies Peptides Associated with the Isomerase Activity of Human Type I (Placental) 3β-Hydroxysteroid Dehydrogenase/IsomeraseBiochemistry, 1997
- Characterization of Structural and Functional Properties of Human 17 -Hydroxysteroid Dehydrogenase Type 1 Using Recombinant Enzymes and Site-Directed MutagenesisMolecular Endocrinology, 1997
- Over-expression of human type I (placental) 3β-hydroxy-5-ene-steroid dehydrogenase/isomerase in insect cells infected with recombinant baculovirusThe Journal of Steroid Biochemistry and Molecular Biology, 1994
- Human placental 3β-hydroxy-5-ene-steroid dehydrogenase and steroid 5→ 4-ene-isomerase: Purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymesJournal of Steroid Biochemistry, 1989
- Human placental 3β-hydroxy-5-ene-steroid dehydrogenase and steroid 5 → 4-ene-isomerase: Purification from microsomes, substrate kinetics, and inhibition by product steroidsJournal of Steroid Biochemistry, 1988
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976