Phylogenetic, structural and functional analyses of the LacI‐GalR family of bacterial transcription factors
- 18 December 1995
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 377 (2) , 98-102
- https://doi.org/10.1016/0014-5793(95)01344-x
Abstract
Phylogenetic tree construction for 25 sequenced members of the LacI-GalR family (LGF) of transcription factors revealed that almost all branches are similar in length, radiating essentially from a single point. This observation suggests that most of these proteins arose by duplication events which occurred at a specific time in evolutionary history, and that further duplication events were rare. Analyses of the multiple alignment of the LGF proteins lead to suggestions regarding structure-function relationships and reveal that the helix-turn-helix DNA-binding motif of LGF proteins is similar in sequence to those of numerous non-homologous DNA-binding proteins.Keywords
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