Glandular Tumors of the Nasal Cavity Induced by Diethylnitrosamine in Syrian Golden Hamsters 2

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Abstract
The morphologic pattern and biologic characteristics of diethylnitrosamine (DEN)-induced glandular tumors of the nasal cavity in hamsters were studied. DEN induced papillary tumors of the surface epithelium, and acinar tumors of the submucous glands. Adenomas, and ultimately papillary adenocarcinomas with squamous metaplasia, were preceded by papillary hyperplasia of the respiratory epithelium. Most of the acinar tumors in the cnterlor nasal cavity were weakly mucin-producing, in contrast to those in the posterior part with mucosa covered by olfactory epithelium, which were strongly mucin-producing. The tubular type, a subtype, was composed of cylindrical cells with little mucin production. These findings show that the DEN-induced tumors originating from the surface epithelium and the submucous gland in Syrian golden hamsters are in many respects similar to such tumors in man.

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