Mechanical Ventilation in Healthy Mice Induces Reversible Pulmonary and Systemic Cytokine Elevation with Preserved Alveolar Integrity
- 1 September 2007
- journal article
- abstracts
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 107 (3) , 419-426
- https://doi.org/10.1097/01.anes.0000278908.22686.01
Abstract
MECHANICAL ventilation (MV) is widely used in general anesthesia and is a lifesaving intervention in critically ill patients. It can, however, induce lung injury in the healthy lung or exacerbate damage in the already injured lung. This has been termed ventilator-induced lung injury (VILI).1,2 Clinical studies show that the use of large tidal volumes (VT≥ 12–15 ml/kg) is associated with a poor prognosis; however, a “lung-protective ventilation strategy” (low tidal volumes [VT< 10–12 ml/kg], optimizing positive end-expiratory pressure [PEEP]) reduces but cannot prevent VILI.1,3–8Keywords
This publication has 0 references indexed in Scilit: