Thyroid and Sarcoplasmic Reticulum Function in Halothane-Sensitive Swine

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Abstract
The rates of utilization of thyroxine and triiodothyronine and the calcium binding ability of sarcoplasmic reticulum fragments were compared in halothane-sensitive and normal swine. Thyroxine clearance rates were determined by monitoring the disappearance of a dose of 1 3 1 I-thyroxine to 10 halothane-sensitive gilts and barrows (five each) with halothane-resistant littermate controls of the same sex. Triiodothyronine clearance rates were determined by the continuous infusion of 1 3 1 I-triiodothyronine to two halothane-positive and two halothane-resistant gilts. Sarcoplasmic reticulum fragments were isolated from muscle biopsies from eight halothane-sensitive and eight halothane-resistant swine and their ability to bind calcium was determined by monitoring the uptake of 4 5 Ca in the presence of ATP. Halothane-sensitive swine were found to have a significantly lower thyroxine half-life, thyroxine fractional disappearance rate, plasma thyroxine concentration and calcium binding by sarcoplasmic reticulum fragments. Halothane-sensitive swine had a significantly greater thyroxine distribution space, thyroxine metabolic clearance rate and triiodothyronine metabolic clearance rate. No differences were noted in the secretion rates of thyroxine or triiodothyronine and plasma concentrations of triiodothyronine. Copyright © 1977. American Society of Animal Science . Copyright 1977 by American Society of Animal Science.

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