The 'Pennies Drop'

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Abstract
Discovery, examined closely, I said to Crick, seemed curiously difficult to pin to a moment or to an insight or even to a single person. "No, I don't think that's curious," Crick said. "I think that's the nature of discoveries, many times: that the reason they're difficult to make is that you've got to take a series of steps, three or four steps, which if you don't make them you won't get there, and if you go wrong in any one of them you won't get there. It isn't a matter of one jump—that would be easy. You've got to make several successive jumps. And usually the pennies drop one after another until eventually it allclicks. Otherwise it would be too easy!"1 This issue ofJAMAis an extension of previousJOURNALpublications this year (1993;269:1040-1045, 1966-1994) designed to mark the 40th anniversary of the 1953 publication of

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