Radiation and the microenvironment – tumorigenesis and therapy
Top Cited Papers
Open Access
- 1 November 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 5 (11) , 867-875
- https://doi.org/10.1038/nrc1735
Abstract
Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.Keywords
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