Poisoning by Organic Phosphorus Pesticides Potentiated by Phenothiazine Derivatives

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Abstract
Repeated administration of the phenothiazine derivatives chlorpromazine and promazine increased the toxicity of a single dose of parathion in male rats. In female rats, a single dose of 5 mg/kg of promazine increased the toxicity of a single dose of parathion, but had no apparent effect on the toxicity of a single dose of Phosdrin. Repeated dosage with chlorpromazine and atropine, or promazine and atropine, after administration of parathion at the same rate, resulted in a slightly higher mortality in female rats than did atropine or no treatment.