Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
Top Cited Papers
Open Access
- 12 April 2007
- journal article
- Published by Springer Nature in BMC Cancer
- Vol. 7 (1) , 64
- https://doi.org/10.1186/1471-2407-7-64
Abstract
Prostate cancer is characterized by heterogeneity in the clinical course that often does not correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of developing metastatic disease. Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets.Keywords
This publication has 48 references indexed in Scilit:
- A molecular correlate to the Gleason grading system for prostate adenocarcinomaProceedings of the National Academy of Sciences, 2006
- Prognostic significance of osteopontin expression in human prostate cancerInternational Journal of Cancer, 2005
- Osteoblasts in prostate cancer metastasis to boneNature Reviews Cancer, 2005
- Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular eventsMolecular Carcinogenesis, 2004
- Molecular determinants of resistance to antiandrogen therapyNature Medicine, 2003
- Plasma osteopontinCancer, 2002
- Gene expression analysis of prostate cancersMolecular Carcinogenesis, 2002
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- Delineation of prognostic biomarkers in prostate cancerNature, 2001
- Significance analysis of microarrays applied to the ionizing radiation responseProceedings of the National Academy of Sciences, 2001