Epistasis and the release of genetic variation during long-term selection
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- 12 March 2006
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 38 (4) , 418-420
- https://doi.org/10.1038/ng1761
Abstract
It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.Keywords
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