Tyrosine Oxidation by NO2 • in Aqueous Solution
Open Access
- 1 August 1984
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 39 (7-8) , 725-727
- https://doi.org/10.1515/znc-1984-7-807
Abstract
Nitrogen dioxide, formed by γ-radiolysis in deaerated aqueous nitrate/nitrite solutions, is capable of oxidizing Gly-Tyr in favourable competition with the natural decay of NO2 • by dimerization and disproportionation. 2,2′-Biphenolic tyrosine dimers and nitro-tyrosine were identified spectroscopically as stable products. The results suggest that NO2 • reacts with the peptide by electron abstraction, generating Gly-Tr phenoxyl radicals (PheO•) which terminate by dimerization (2 PheO• → 2,2′-biphenol) and NO2 • -scavenging (PheO• + NO2 • → Nitro-Tyr).Keywords
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