De- and regeneration of axons after minor lesions in the rat sciatic nerve. Effects of microneurography electrode penetrations

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Abstract
The structural effects of microneurography electrode penetrations were examined in the rat sciatic nerve. Such penetrations always produced restricted peri- and endoneurial lesions, resulting in degeneration of myelinated and unmyelinated axons, as well as in demyelination. The regenerative response was vigorous, and the regenerating axons usually formed a separate region or fascicle. However, restitution was not complete after 9 weeks survival, and in some cases not even after 16 weeks.